Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease-Reference-Cited by-同舟云学术

Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease

Published:2022-08-09 Issue:9 Volume:23 Page:3822-3830
ISSN:1525-7797
Container-title:Biomacromolecules
language:en
Short-container-title:Biomacromolecules

Author:

Vunnam Nagamani¹,Hansen Scott¹,Williams Dillon C.¹,Been MaryJane Olivia¹,Lo Chih Hung¹,Pandey Anil K.¹,Paulson Carolyn N.¹^ORCID,Rohde John A.²,Thomas David D.²,Sachs Jonathan N.¹^ORCID,Wood David K.¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States

Funder

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.2c00671

Reference42 articles.

1. GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions

2. GBT 440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

3. L-glutamine for sickle cell disease: more than reducing redox

4. Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

5. Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia

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