Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases-Reference-Cited by-同舟云学术

Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases

Published:2013-02-26 Issue:5 Volume:56 Page:2059-2073
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Addie Matt¹,Ballard Peter¹,Buttar David¹,Crafter Claire¹,Currie Gordon¹,Davies Barry R.¹,Debreczeni Judit¹,Dry Hannah¹,Dudley Philippa¹,Greenwood Ryan¹,Johnson Paul D.¹,Kettle Jason G.¹,Lane Clare¹,Lamont Gillian¹,Leach Andrew¹,Luke Richard W. A.¹,Morris Jeff¹,Ogilvie Donald¹,Page Ken¹,Pass Martin¹,Pearson Stuart¹,Ruston Linette¹

Affiliation:

1. Oncology iMed, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301762v

Reference18 articles.

1. Targeting the phosphoinositide 3-kinase pathway in cancer

2. AKT/PKB Signaling: Navigating Downstream

3. PIKKing on PKB: regulation of PKB activity by phosphorylation