1. Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario, M5S 3G8 Canada, Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5 Canada, and Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada