Process Research and Development of an NK-1 Receptor Antagonist. Enantioselective Trifluoromethyl Addition to a Ketone in the Preparation of a Chiral Isochroman

Author:

Caron Stéphane1,Do Nga M.1,Sieser Janice E.1,Arpin Patrice1,Vazquez Enrique1

Affiliation:

1. Chemical R&D, Pfizer Global R&D, MS-8118D/4002, Eastern Point Road, Groton, Connecticut 06340, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference29 articles.

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3. Ito, F.; Kondo, H.; Shimada, K.; Nakane, M.; Lowe, J. A., III; Rosen, T. J.; Yang, B. V.Preparation of 2-diphenylmethyl-3-benzylaminoquinuclidinesas substance P antagonists. 92-US33179221677, 19920428,1999.

4. Satake, K.Preparation ofN-(isobenzofuranylmethyl)piperidinamines and analogs as substanceP receptor antagonists.98-IB17049925714, 19981026,1999.

5. 1,2-Di(lithiomethyl)benzene from phthalan: Sequential introduction of two different electrophiles

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