Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid-Reference-Cited by-同舟云学术

Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid

Published:2010-04-15 Issue:9 Volume:53 Page:3454-3464
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McKenna Charles E.¹,Kashemirov Boris A.¹,Błażewska Katarzyna M.¹,Mallard-Favier Isabelle¹,Stewart Charlotte A.²,Rojas Javier²,Lundy Mark W.³,Ebetino Frank H.³,Baron Rudi A.⁴,Dunford James E.⁵,Kirsten Marie L.⁴,Seabra Miguel C.⁴,Bala Joy L.¹,Marma Mong S.¹,Rogers Michael J.²,Coxon Fraser P.²

Affiliation:

1. Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744

2. Bone & Musculoskeletal Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, U.K.

3. Procter & Gamble Pharmaceuticals, Mason, Ohio 45040

4. Molecular Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, U.K.

5. Nuffield Department of Orthopaedic Surgery, Oxford University, Institute of Musculoskeletal Sciences, Nuffield Orthopaedic Center, Headington, Oxford OX3 7LD, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900232u

Reference60 articles.

1. Bisphosphonate Inhibitors of Toxoplasma gondi Growth: In Vitro, QSAR, and In Vivo Investigations

2. Bisphosphonate actions: Physical chemistry revisited

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4. Bisphosphonate Inhibition of the Exopolyphosphatase Activity of the Trypanosoma brucei Soluble Vacuolar Pyrophosphatase

5. Activity of Nitrogen-Containing and Non-Nitrogen-Containing Bisphosphonates on Tumor Cell Lines

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