A Rational Approach to the Design of Selective Substrates and Potent Nontransportable Inhibitors of the Excitatory Amino Acid Transporter EAAC1 (EAAT3). New Glutamate and Aspartate Analogues as Potential Neuroprotective Agents-Reference-Cited by-同舟云学术

A Rational Approach to the Design of Selective Substrates and Potent Nontransportable Inhibitors of the Excitatory Amino Acid Transporter EAAC1 (EAAT3). New Glutamate and Aspartate Analogues as Potential Neuroprotective Agents

Published:2001-07-12 Issue:16 Volume:44 Page:2507-2510
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Campiani Giuseppe¹,De Angelis Meri¹,Armaroli Silvia¹,Fattorusso Caterina¹,Catalanotti Bruno¹,Ramunno Anna¹,Nacci Vito¹,Novellino Ettore¹,Grewer Christof¹,Ionescu Diana¹,Rauen Thomas¹,Griffiths Roger¹,Sinclair Colin¹,Fumagalli Elena¹,Mennini Tiziana¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Universita' degli Studi di Salerno, via Ponte Don Melillo 11, 84084 Fisciano, Italy, Dipartimento Farmaco Chimico Tecnologico, Universita' degli Studi di Siena, via Aldo Moro, 53100 Siena, Italy, Dipartimento di Chimica delle Sostanze Naturali and Dipartimento di Chimica Farmaceutica e Tossicologica, Universita' degli Studi di Napoli “Federico II”, via D. Montesano 49, 80131 Napoli, Italy, Max-Planck Institut fur Biophysik, Frankfurt/Main, Germany, Institute fur...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm015509z

Reference19 articles.

1. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

2. High Affinity Glutamate Transporters: Regulation of Expression and Activity

3. The role of glutamate transporters in glutamate homeostasis in the brain.

4. Na+-dependent Glutamate Transporters (EAAT1, EAAT2, and EAAT3) of the Blood-Brain Barrier

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