Microwave-assisted rapid synthesis of chiral oxazolines-Reference-Cited by-同舟云学术

Microwave-assisted rapid synthesis of chiral oxazolines

Published:2023 Issue:11 Volume:21 Page:2312-2319
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Deng Haowen¹²³⁴^ORCID,Wang Jianshe⁵,He Wei⁶,Ye Yang¹²³⁴^ORCID,Bai Renren¹²³⁴,Zhang Xuelei¹²³⁴,Ye Xiang-Yang¹²³⁴^ORCID,Xie Tian¹²³⁴,Hui Zi¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China

2. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, China

3. Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, China

4. Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, China

5. Drug Discovery, Hangzhou PurpleCrystal Pharma Co. Ltd, Hangzhou, Zhejiang 311121, China

6. Chemical Manufacturing and Control, Adlai Nortye Ltd, Hangzhou, Zhejiang 311121, China

Abstract

A practical protocol involving microwave-assisted cyclization of nitriles and chiral amino indanols has been successfully developed. This enables quick access to chiral oxazolines using a reusable catalyst in a much shorter reaction time.

Funder

Ministry of Science and Technology of the People's Republic of China

Department of Health of Zhejiang Province

National Natural Science Foundation of China

Hangzhou Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02192G

Reference61 articles.

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3. A Rational Approach to the Design of Selective Substrates and Potent Nontransportable Inhibitors of the Excitatory Amino Acid Transporter EAAC1 (EAAT3). New Glutamate and Aspartate Analogues as Potential Neuroprotective Agents

4. Synthesis, antimycobacterial and cytotoxic activity of α,β-unsaturated amides and 2,4-disubstituted oxazoline derivatives

5. Three new oxazoline alkaloids from Gymnotheca chinensis

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