An Enantioselective Synthesis of (2S,3R)-3-(N-Benzyloxycarbonyl)amino-1-chloro-4-phenylthiobutan-2-ol, a Central Intermediate of Nelfinavir1
Author:
Affiliation:
1. Research and Development Center, Nagase & Co., Ltd., 2-2-3 Murotani, Nishi-ku, Kobe, 651-2241 Japan
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op010073i
Reference19 articles.
1. A systematic study of P1–P3 spanning sidechains for the inhibition of HIV-1 protease
2. Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease
3. A Practical Synthesis of Nelfinavir, an HIV-Protease Inhibitor, Using a Novel Chiral C4 Building Block: (5R,6S)-2,2-Dimethyl-5-hydroxy-1,3-dioxepan-6-ylammonium Acetate
4. (1S)-1-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylammonium Benzoate, A Versatile Building Block for Chiral 2-Aminoalkanols: Concise Synthesis and Application to Nelfinavir, a Potent HIV-Protease Inhibitor
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