A Practical Synthesis of Nelfinavir, an HIV-Protease Inhibitor, Using a Novel Chiral C4 Building Block: (5R,6S)-2,2-Dimethyl-5-hydroxy-1,3-dioxepan-6-ylammonium Acetate-Reference-Cited by-同舟云学术

A Practical Synthesis of Nelfinavir, an HIV-Protease Inhibitor, Using a Novel Chiral C4 Building Block: (5R,6S)-2,2-Dimethyl-5-hydroxy-1,3-dioxepan-6-ylammonium Acetate

Published:1998-10-01 Issue:22 Volume:63 Page:7582-7583
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Inaba Takashi¹,Birchler Angela G.¹,Yamada Yasuki¹,Sagawa Shoichi¹,Yokota Katsuyuki¹,Ando Koji¹,Uchida Itsuo¹

Affiliation:

1. Central Pharmaceutical Research Institute, Japan Tobacco, Inc., 1-1, Murasaki-cho Takatsuki Osaka, 569-1125, Japan, and Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo981472n

Reference12 articles.

1. Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease

2. Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

3. Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines.

4. A Convenient, Large Scale Synthesis of N-CBZ-(S-Phenyl)-L-Cysteine

Cited by 38 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. β-amino alcohols as promising inhibitory candidates against the SARS-CoV-2, A theoretical design based on MD simulation and DFT insights;Computational and Theoretical Chemistry;2024-09

2. A review on synthesis of antiviral drugs, in silico studies and their toxicity;Journal of the Indian Chemical Society;2023-03

3. Enantioselective Epoxide Opening;Organic Reactions;2022-06-13

4. Divergent approach to the synthesis of (-)-balanol heterocycle and cis-3-hydroxypipecolic acid based on chiral 2-aminoalkanol equivalent;Tetrahedron;2021-01

5. Biocatalytic routes to anti-viral agents and their synthetic intermediates;Chemical Society Reviews;2021