Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain-Reference-Cited by-同舟云学术

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

Published:2013-10-14 Issue:20 Volume:56 Page:8019-8031
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Xiao-Tao¹,Pitis Philip¹,Liu Guodong¹,Yuan Catherine¹,Gotchev Dimitar¹,Cowan Conrad L.¹,Rominger David H.¹,Koblish Michael¹,DeWire Scott M.¹,Crombie Aimee L.¹,Violin Jonathan D.¹,Yamashita Dennis S.¹

Affiliation:

1. Trevena, Inc., 1018 West 8th Avenue, Suite A, King of Prussia, Pennsylvania 19406, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4010829

Reference32 articles.

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2. Mu opioid receptor regulation and opiate responsiveness

3. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

4. Opiate receptor knockout mice define receptor roles in endogenous nociceptive responses and morphine-induced analgesia

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