Physicochemically and Pharmacokinetically Stable Nonapeptide KISS1 Receptor Agonists with Highly Potent Testosterone-Suppressive Activity
Author:
Affiliation:
1. Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa 251-8555, Japan
2. Pharmaceutical Production Division, Takeda Pharmaceutical Company Ltd., Osaka 532-8686, Japan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm5005489
Reference32 articles.
1. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor
2. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
3. AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1
4. New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
5. The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction
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