Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility-Reference-Cited by-同舟云学术

Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility

Published:2016-09-21 Issue:19 Volume:59 Page:8804-8811
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nishizawa Naoki¹,Takatsu Yoshihiro¹,Kumano Satoshi¹,Kiba Atsushi¹,Ban Junko²,Tsutsumi Shunichirou²,Matsui Hisanori¹,Matsumoto Shin-ichi¹,Yamaguchi Masashi¹,Ikeda Yukihiro²,Kusaka Masami²,Ohtaki Tetsuya¹,Itoh Fumio¹,Asami Taiji¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, Fujisawa 251-8555, Japan

2. CMC Center, Takeda Pharmaceutical Company Ltd, Osaka 532-8686, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00379

Reference36 articles.

1. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

2. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54