Development of a Scalable Synthesis of Gastrazole (JB95008): A Potent CCK2 Receptor Antagonist-Reference-Cited by-同舟云学术

Development of a Scalable Synthesis of Gastrazole (JB95008): A Potent CCK2 Receptor Antagonist

Published:2005-06-24 Issue:4 Volume:9 Page:499-507
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ormerod Dominic¹,Willemsens Bert¹,Mermans Rit¹,Langens Jaak¹,Winderickx Guy¹,Kalindjian S. Barret¹,Buck Ildiko M.¹,McDonald Iain M.¹

Affiliation:

1. Chemical Process Research, Johnson & Johnson Pharmaceutical Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium, Analytical Department, Johnson & Johnson Pharmaceutical Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium, and James Black Foundation, 68 Half Moon Lane, London SE24 9JE, UK

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op0500638

Reference9 articles.

1. Improving the Affinity and Selectivity of a Nonpeptide Series of Cholecystokinin-B/Gastrin Receptor Antagonists Based on the Dibenzobicyclo[2.2.2]octane Skeleton

2. Non-Peptide Cholecystokinin-B/Gastrin Receptor Antagonists Based on Bicyclic, Heteroaromatic Skeletons

3. Use of a novel CCKB/gastrin receptor antagonist, gastrazole (JB5008) in patients with advanced pancreatic adenocarcinoma. Results of an open labeled pilot trial

4. New convenient reagent for peptide syntheses

5. Action of Trifluoroacetic Anhydride on N-Substituted Amic Acids1,2

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Diphenyl carbonate mediated synthesis of amides of carboxylic acids: Facile synthesis of drug molecules and drug intermediates;Tetrahedron Letters;2023-07

2. A one-step base-free synthesis of N-arylamides via modified pivaloyl mixed anhydride mediated amide coupling;Organic & Biomolecular Chemistry;2023

3. Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution;Organic Process Research & Development;2022-06-07

4. Fluorinated phenylalanines: synthesis and pharmaceutical applications;Beilstein Journal of Organic Chemistry;2020-05-15

5. Applications of fluorine-containing amino acids for drug design;European Journal of Medicinal Chemistry;2020-01