A one-step base-free synthesis of <i>N</i>-arylamides <i>via</i> modified pivaloyl mixed anhydride mediated amide coupling-Reference-Cited by-同舟云学术

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A one-step base-free synthesis of N-arylamides via modified pivaloyl mixed anhydride mediated amide coupling

Published:2023 Issue:18 Volume:21 Page:3825-3828
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mao Fenghua¹,Jin Can¹,Wang Jie¹,Yang Hui¹,Yan Xinhuan¹^ORCID,Li Xiaoqing¹^ORCID,Xu Xiangsheng¹^ORCID

Affiliation:

1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China

Abstract

Pivalic anhydride is shown to be an effective reagent for direct amidation of carboxylic acids with N-alkyl anilines under base-free conditions.

Funder

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00452J

Reference62 articles.

1. Rethinking amide bond synthesis

2. A green chemistry perspective on catalytic amide bond formation

3. Recent developments in catalytic amide bond formation

4. Challenges and outlook for catalytic direct amidation reactions

5. Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

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