Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria

Author:

Maveyraud Laurent1,Mourey Lionel1,Kotra Lakshmi P.1,Pedelacq Jean-Denis1,Guillet Valérie1,Mobashery Shahriar1,Samama Jean-Pierre1

Affiliation:

1. Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologie Structurale du CNRS, 205 route de Narbonne, 31077-Toulouse Cedex, France, and Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference26 articles.

1. Hospital-acquired infections: diseases with increasingly limited therapies.

2. Impact of changing pathogens and antimicrobial susceptibility patterns in the treatment of serious infections in hospitalized patients

3. Davies, J. E.Antibiotic resistance:  origins, evolution, selection andspread;Ciba Foundation Symposium 207; Chadwick, D. J., Goode, J., Eds.; John-Wiley:  Chichester, 1997; pp 15−35.

4. The Crisis in Antibiotic Resistance

5. Nomenclature of TEM beta-lactamases

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