Capping Parallel β-Sheets of Acetyl(Ala)6NH2 with an Acetyl(Ala)5ProNH2 Can Arrest the Growth of the Sheet, Suggesting a Potential for Curtailing Amyloid Growth. An ONIOM and Density Functional Theory Study-Reference-Cited by-同舟云学术

Capping Parallel β-Sheets of Acetyl(Ala)6NH2 with an Acetyl(Ala)5ProNH2 Can Arrest the Growth of the Sheet, Suggesting a Potential for Curtailing Amyloid Growth. An ONIOM and Density Functional Theory Study

Published:2014-01-23 Issue:4 Volume:53 Page:617-623
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Pohl Gabor¹,Asensio Amparo²,Dannenberg J. J.¹

Affiliation:

1. Department of Chemistry, City University of New York, Hunter College and the Graduate School, 695 Park Avenue, New York, New York 10065, United States

2. Facultad de Farmacia, Departamento Quimica Organica, Universidad de Valencia, Avda Vicente Andres Estelles, 46100 Burjassot, Valencia, Spain

Funder

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi401366w

Reference54 articles.

1. The Energetic and Structural Effects of Single Amino Acid Substitutions upon Capped α-Helical Peptides Containing 17 Amino Acid Residues. An ONIOM DFT/AM1 Study

2. Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register -sheet structure