The unusual metal ion binding ability of histidyl tags and their mutated derivatives

Author:

Brasili Davide1234,Watly Joanna5678,Simonovsky Eyal59101112,Guerrini Remo1234,Barbosa Nuno A.5678,Wieczorek Robert5678,Remelli Maurizio1234,Kozlowski Henryk5678,Miller Yifat59101112

Affiliation:

1. Department of Chemical and Pharmaceutical Sciences

2. University of Ferrara

3. I-44121 Ferrara

4. Italy

5. Department of Chemistry

6. University of Wroclaw

7. 50-383 Wroclaw

8. Poland

9. Ben Gurion University of the Negev

10. Beer-Sheva 84105

11. Israel

12. Ilse Katz Institute for Nanoscale Science and Technology

Abstract

Peptides that consist of repeated sequences of alternating histidines and alanines strongly bind Cu(ii) and form α-helical structures.

Funder

United States - Israel Binational Science Foundation

Ministerstwo Nauki i Szkolnictwa Wyzszego

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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