Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout-Reference-Cited by-同舟云学术

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Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout

Published:2021-07-28 Issue:31 Volume:93 Page:10999-11009
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Al-Amin Rasel A.¹^ORCID,Gallant Caroline J.¹,Muthelo Phathutshedzo M.¹,Landegren Ulf¹

Affiliation:

1. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala SE-751 08, Sweden

Funder

Vetenskapsr??det

IngaBritt och Arne Lundbergs Forskningsstiftelse

Torsten S??derbergs Stiftelse

Stiftelsen f??r??Strategisk Forskning

FP7 Ideas: European Research Council

Swedish Collegium for Advanced Studies

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.1c02225

Reference39 articles.

1. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

2. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

3. Target validation using chemical probes

4. Determining target engagement in living systems

5. An analysis of the attrition of drug candidates from four major pharmaceutical companies

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