Development and Application of Ultra-Performance Liquid Chromatography-TOF MS for Precision Large Scale Urinary Metabolic Phenotyping

Author:

Lewis Matthew R.12,Pearce Jake T. M.12,Spagou Konstantina2,Green Martin3,Dona Anthony C.12,Yuen Ada H. Y.1,David Mark1,Berry David J.1,Chappell Katie1,Horneffer-van der Sluis Verena1,Shaw Rachel12,Lovestone Simon4,Elliott Paul5,Shockcor John2,Lindon John C.2,Cloarec Olivier6,Takats Zoltan2,Holmes Elaine2,Nicholson Jeremy K.12

Affiliation:

1. MRC-NIHR National Phenome Centre, Department of Surgery and Cancer, Imperial College London, IRDB Building, Du Cane Road, London W12 0NN, United Kingdom

2. Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, United Kingdom

3. Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow SK9 4AX, United Kingdom

4. Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom

5. MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, United Kingdom

6. Korrigan Sciences Ltd., 38 Wakemans, Upper Basildon, Reading RG8 8JE, United Kingdom

Funder

Medical Research Council

National Institute for Health Research

Home Office

Public Health England

Imperial College Healthcare NHS Trust

Imperial College Biomedical Research Centre

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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