Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues

Author:

Holst Stephanie1,Heijs Bram1,de Haan Noortje1,van Zeijl René J. M.1,Briaire-de Bruijn Inge H.2,van Pelt Gabi W.3,Mehta Anand S.4,Angel Peggy M.5,Mesker Wilma E.3,Tollenaar Rob A.3,Drake Richard R.5,Bovée Judith V. M. G.2,McDonnell Liam A.126,Wuhrer Manfred1

Affiliation:

1. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands

2. Department of Pathology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands

3. Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands

4. Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, Pennsylvania 19102, United States

5. Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, United States

6. Fondazione Pisana per la Scienza ONLUS, c/o Croce Rossa Italiana, via Panfilo Castaldi 2, 56121, Ospedaletto, Pisa, Italy

Funder

National Cancer Institute

The Commonwealth of Pennsylvania

IBD-BIOM

National Institutes of Health/National Cancer Institute

European Union Seventh Framework Programmes HighGlycan project

Hepatitis B Foundation

ZonMW Zenith project Imaging Mass Spectrometry-Based Molecular Histology: Differentiation and Characterization of Clinically Challenging Soft Tissue Sarcomas

state of South Carolina SmartState Endowed Research program

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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