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Delineating cancer evolution with single-cell sequencing

Published:2015-07-15 Issue:296 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Navin Nicholas E.¹²³

Affiliation:

1. Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Bioinformatics and Computational Biology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

3. Graduate Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Abstract

Single-cell sequencing methods are revolutionizing cancer research and medicine by providing powerful tools to investigate intratumor heterogeneity and rare subpopulations.

Funder

National Cancer Institute

MD Anderson Cancer Center

Nadia's Gift Foundation Damon Runyon-Rachleff Innovator

Lefkofsky Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference10 articles.

1. Tumour evolution inferred by single-cell sequencing

2. Large-Scale Copy Number Polymorphism in the Human Genome

3. Inferring tumor progression from genomic heterogeneity

4. PROBER: oligonucleotide FISH probe design software

5. A genetic model for colorectal tumorigenesis

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