Untargeted Detection of HIF Stabilizers in Doping Samples: Activity-Based Screening with a Stable In Vitro Bioassay
Author:
Affiliation:
1. Laboratory of Toxicology, Department of Bioanalysis, Ghent University, 9000 Ghent, Belgium
2. Doping Control Laboratory, Department Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium
Funder
Partnership for Clean Competition
Bijzonder Onderzoeksfonds UGent
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.3c03816
Reference41 articles.
1. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
2. Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications
3. Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies
4. Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis
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1. The ‘ABC’ of split-nanoluciferase HIF heterodimerization bioassays: Applications, Benefits & Considerations;Biochemical Pharmacology;2024-11
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