Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation-Reference-Cited by-同舟云学术

Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation

Published:2019-08-05 Issue:17 Volume:91 Page:11388-11396
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Niyonsaba Edouard¹^ORCID,Easton McKay W.¹^ORCID,Feng Erlu¹,Yu Zaikuan¹,Zhang Zhoupeng²,Sheng Huaming³,Kong John³,Easterling Leah F.¹,Milton Jacob¹,Chobanian Harry R.²,Deprez Nicholas R.⁴,Cancilla Mark T.²,Kilaz Gozdem⁵^ORCID,Kenttämaa Hilkka I.¹^ORCID

Affiliation:

1. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Pharmacokinetics, Pharmacodynamics, & Drug Metabolism, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

3. Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

4. Process Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

5. Purdue University, School of Engineering Technology, West Lafayette, Indiana 47907, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b02717

Reference34 articles.

1. UDP-Glucuronosyltransferases

2. Advances in drug metabolism and pharmacogenetics research in Australia

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