Mechanistic Characterization of the HDV Genomic Ribozyme: Solvent Isotope Effects and Proton Inventories in the Absence of Divalent Metal Ions Support C75 as the General Acid-Reference-Cited by-同舟云学术

Mechanistic Characterization of the HDV Genomic Ribozyme: Solvent Isotope Effects and Proton Inventories in the Absence of Divalent Metal Ions Support C75 as the General Acid

Published:2008-10-09 Issue:44 Volume:130 Page:14504-14520
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Cerrone-Szakal Andrea L.¹,Siegfried Nathan A.¹,Bevilacqua Philip C.¹

Affiliation:

1. Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja801816k

Reference76 articles.

1. Nucleobase catalysis in ribozyme mechanism

2. Functional Identification of Catalytic Metal Ion Binding Sites within RNA

3. Structural Evidence for a Two-Metal-Ion Mechanism of Group I Intron Splicing

4. Alternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme Chemistry

5. The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

Cited by 43 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Beyond the Plateau: pL Dependence of Proton Inventories as a Tool for Studying Ribozyme and Ribonuclease Catalysis;Biochemistry;2021-09-08

2. Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State;Biochemistry;2018-05-07

3. Allosteric Modulation of the Faecalibacterium prausnitzii Hepatitis Delta Virus-like Ribozyme by Glucosamine 6-Phosphate: The Substrate of the Adjacent Gene Product;Biochemistry;2017-11-03

4. A Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme Activation;ACS Catalysis;2016-02-18

5. Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations;Journal of the American Chemical Society;2015-07-14