Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models: Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites-Reference-Cited by-同舟云学术

Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models: Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

Published:1998-03-01 Issue:12 Volume:37 Page:4137-4147
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Korzekwa K. R.¹,Krishnamachary N.¹,Shou M.¹,Ogai A.¹,Parise R. A.¹,Rettie A. E.¹,Gonzalez F. J.¹,Tracy T. S.¹

Affiliation:

1. Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15217, Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi9715627

Reference36 articles.

1. Cytochrome P450 and Aromatic Bases: A 1H NMR Study

2. [20] Substrate inhibition

3. Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.

4. [8] Expression of mammalian cytochrome P450 using vaccinia virus

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