Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design-Reference-Cited by-同舟云学术

Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design

Published:2008-07-26 Issue:16 Volume:51 Page:4986-4999
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wyatt Paul G.¹,Woodhead Andrew J.¹,Berdini Valerio¹,Boulstridge John A.¹,Carr Maria G.¹,Cross David M.¹,Davis Deborah J.¹,Devine Lindsay A.¹,Early Theresa R.¹,Feltell Ruth E.¹,Lewis E. Jonathan¹,McMenamin Rachel L.¹,Navarro Eva F.¹,O’Brien Michael A.¹,O’Reilly Marc¹,Reule Matthias¹,Saxty Gordon¹,Seavers Lisa C. A.¹,Smith Donna-Michelle¹,Squires Matt S.¹,Trewartha Gary¹,Walker Margaret T.¹,Woolford Alison J.-A.¹

Affiliation:

1. Astex Therapeutics Ltd, 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800382h

Reference52 articles.

1. Fragment-Based Lead Discovery Using X-ray Crystallography

2. Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

3. Recent Developments in Fragment-Based Drug Discovery

4. Fragment-based approaches to enzyme inhibition

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