An Improved Synthesis of the Selective Matrix Metalloproteinase Inhibitor, Ro 28-2653
Author:
Affiliation:
1. Chemical Synthesis - Process Research, Non-Clinical Development, Pre-Clinical Research and Development, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110, U.S.A.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op049965j
Reference7 articles.
1. Pyrimidine-2,4,6-Triones: A New Effective and Selective Class of Matrix Metalloproteinase Inhibitors
2. Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors
3. The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model
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