Discovery and Optimization of 1,3,4-Trisubstituted-pyrazolone Derivatives as Novel, Potent, and Nonsteroidal Farnesoid X Receptor (FXR) Selective Antagonists-Reference-Cited by-同舟云学术

Discovery and Optimization of 1,3,4-Trisubstituted-pyrazolone Derivatives as Novel, Potent, and Nonsteroidal Farnesoid X Receptor (FXR) Selective Antagonists

Published:2012-08-10 Issue:16 Volume:55 Page:7037-7053
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Huang¹,Yu Ying¹,Gao Zhenting¹,Zhang Yong²,Li Chenjing³,Xu Xing³,Jin Hui¹,Yan Wenzhong¹,Ma Ruoqun¹,Zhu Jin¹,Shen Xu¹³,Jiang Hualiang¹³,Chen Lili³,Li Jian¹

Affiliation:

1. Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China

2. Department of Biochemistry, Zunyi Medical College, 201 Dalian Road, Zunyi, Guizhou 563003, China

3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3002718

Reference36 articles.

1. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

2. Identification of a Nuclear Receptor for Bile Acids

3. FXR: a promising target for the metabolic syndrome?

4. Farnesoid X Receptor Responds to Bile Acids and Represses Cholesterol 7α-Hydroxylase Gene (CYP7A1) Transcription

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