Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo-Reference-Cited by-同舟云学术

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Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo

Published:2022-12 Issue: Volume:129 Page:106203
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Wang Shaorong,Huan Yi,Niu Shuaishuai,Cao Hui,Yang Mingyan,Zhou Xinyue,Gao Xuefeng,Wang Xing,Shen Zhufang,Fang Wei-Shuo

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference21 articles.

1. Farnesoid X receptor: from structure to potential clinical applications;Pellicciari;J. Med. Chem.,2005

2. Bile Acids and Their Receptors,2019

3. Recent advances in the medicinal chemistry of farnesoid X receptor;Fang;J. Med. Chem.,2021

4. A natural product that lowers cholesterol as an antagonist ligand for FXR;Urizar;Science,2002

5. Medicinal chemistry and pharmacological effects of farnesoid X receptor (FXR) antagonists;Lamers;Curr. Top Med. Chem.,2014

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications;Acta Pharmaceutica Sinica B;2024-08

2. Harnessing Oleanolic Acid and Its Derivatives as Modulators of Metabolic Nuclear Receptors;Biomolecules;2023-09-28

3. Structure Optimization of 12β-O-γ-Glutamyl Oleanolic Acid Derivatives Resulting in Potent FXR Antagonist/Modulator for NASH Therapy;Pharmaceuticals;2023-05-17

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