Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)
Author:
Affiliation:
1. AstraZeneca, Oncology Innovative Medicines, Gatehouse Park, Waltham, Massachusetts 02451, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm400822z
Reference51 articles.
1. Epidermal growth factor receptor (EGFR) signaling in cancer
2. Epidermal growth factor receptor mutations in lung cancer
3. Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
4. Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR
5. EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
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