PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete-Reference-Cited by-同舟云学术

PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete

Published:2017-03-23 Issue:4 Volume:80 Page:1200-1204
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Larson Charles B.¹²,Crüsemann Max¹,Moore Bradley S.¹³^ORCID

Affiliation:

1. Center for Marine Biotechnology & Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92037, United States

2. Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093, United States

3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, United States

Funder

Deutsche Forschungsgemeinschaft

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.6b01121

Reference27 articles.

1. The re-emergence of natural products for drug discovery in the genomics era

2. Natural products: A continuing source of novel drug leads

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4. Medema, M. H.; Breitling, R.; Takano, E.Synthetic Biology in Streptomyces Bacteria;Academic Press, 2011; Vol.497, pp485–502.

5. Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

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