Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors-Reference-Cited by-同舟云学术

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors

Published:2015-11-20 Issue:12 Volume:78 Page:2867-2879
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Iranshahi Mehrdad¹,Chini Maria Giovanna²,Masullo Milena²,Sahebkar Amirhossein¹,Javidnia Azita³,Chitsazian Yazdi Mahsa¹,Pergola Carlo⁴,Koeberle Andreas⁴,Werz Oliver⁴,Pizza Cosimo²,Terracciano Stefania²,Piacente Sonia²,Bifulco Giuseppe²

Affiliation:

1. Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Vakil Abad Boulevard, Opposite Mellat Park, 91775-1365 Mashhad, Iran

2. Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy

3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Enghlab Street, 14155-6559 Tehran, Iran

4. Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, Germany

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.5b00700

Reference73 articles.

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2. The Clinical Applications of Curcumin: Current State and the Future

3. Dissecting the Pharmacophore of Curcumin. Which Structural Element Is Critical for Which Action?

4. SAR Studies on Curcumin’s Pro-inflammatory Targets: Discovery of Prenylated Pyrazolocurcuminoids as Potent and Selective Novel Inhibitors of 5-Lipoxygenase

5. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

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