hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala
Author:
Affiliation:
1. Institute of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria
2. National Museum, P.O. Box 266, Bloemfontein 9300, South Africa
Funder
European Commission Directorate-General for Research and Innovation
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.5b00344
Reference40 articles.
1. Kerns, E. H.; Di, L.Drug-like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization;Academic Press:Burlington, MA, 2008; p209.
2. The hERG potassium channel and hERG screening for drug-induced torsades de pointes
3. Collation, assessment and analysis of literaturein vitrodata on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties
4. Drug induced QT prolongation and torsades de pointes
5. hERG potassium channels and cardiac arrhythmia
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