Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts

Author:

Cheng Ken Chih-Chien1,Cao Shugeng23,Raveh Avi4,MacArthur Ryan1,Dranchak Patricia1,Chlipala George4,Okoneski Matthew T.45,Guha Rajarshi1,Eastman Richard T.6,Yuan Jing6,Schultz Pamela J.4,Su Xin-zhuan6,Tamayo-Castillo Giselle7,Matainaho Teatulohi8,Clardy Jon3,Sherman David H.45,Inglese James1

Affiliation:

1. National Center of Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States

2. Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai’i at Hilo, Hilo, Hawaii 96720, United States

3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, C-643, Boston, Massachusetts 021151, United States

4. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, United States

5. Departments of Medicinal Chemistry, Chemistry, and Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan 48109-2216, United States

6. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20852, United States

7. Unidad Estrategica de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Costa Rica & CIPRONA-Escuela de Química, Universidad de Costa Rica, 2060 San Pedro, Costa Rica

8. School of Medicine and Health Sciences, University of Papua New Guinea, Boroko, Papua New Guinea

Funder

National Center for Advancing Translational Sciences

Fogarty International Center

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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