Spiroarborin, an <i>ent</i>-Clerodane Homodimer from <i>Callicarpa arborea</i> as an Inhibitor of the Eleven-Nineteen Leukemia (ENL) Protein by Targeting the YEATS Domain-Reference-Cited by-同舟云学术

Spiroarborin, an ent-Clerodane Homodimer from Callicarpa arborea as an Inhibitor of the Eleven-Nineteen Leukemia (ENL) Protein by Targeting the YEATS Domain

Published:2022-01-14 Issue:2 Volume:85 Page:317-326
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Pu De-Bing¹^ORCID,Guo Si-Qi²³,Ni Dong-Xuan¹,Lin Jing¹,Gao Jun-Bo⁴,Li Xiao-Ning⁵,Zhang Rui-Han¹,Li Xiao-Li¹,Luo Cheng²⁶^ORCID,Chen Shi-Jie²⁶,Xiao Wei-Lie¹^ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People’s Republic of China

2. The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China

3. School of Pharmacy, Nanchang University, Nanchang 330006, People’s Republic of China

4. State Key Laboratory of CAD&CG, Zhejiang University, Hangzhou 310058, People’s Republic of China

5. School of Pharmaceutical Sciences, Yunnan University of Chinese Medicine, Kunming 650500, People’s Republic of China

6. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China

Funder

the Science and Technology Commission of Shanghai Municipality

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.1c00775

Reference37 articles.

1. Translating the Histone Code

2. Epigenetic protein families: a new frontier for drug discovery

3. ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

4. Transcription control by the ENL YEATS domain in acute leukaemia

5. Impaired cell fate through gain-of-function mutations in a chromatin reader

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