Synthesis and SAR of Adatanserin: Novel Adamantyl Aryl- and Heteroarylpiperazines with Dual Serotonin 5-HT1A and 5-HT2 Activity as Potential Anxiolytic and Antidepressant Agents-Reference-Cited by-同舟云学术

Synthesis and SAR of Adatanserin: Novel Adamantyl Aryl- and Heteroarylpiperazines with Dual Serotonin 5-HT1A and 5-HT2 Activity as Potential Anxiolytic and Antidepressant Agents

Published:1999-11-25 Issue:25 Volume:42 Page:5077-5094
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Abou-Gharbia Magid A.¹,Childers Wayne E.¹,Fletcher Horace¹,McGaughey Georgia¹,Patel Usha¹,Webb Michael B.¹,Yardley John¹,Andree Terrance¹,Boast Carl¹,Kucharik Robert J.¹,Marquis Karen¹,Morris Herman¹,Scerni Rosemary¹,Moyer John A.¹

Affiliation:

1. Chemical Sciences and CNS Disorders, Wyeth-Ayerst Research, CN 8000, Princeton, New Jersey 08543-8000

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9806704

Reference84 articles.

1. Preclinical profile of the pyrimidinylpiperazinyl imide compound WY-47,846: A potential anxiolytic

2. WY-47846

3. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors

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