Synthesis and biological evaluation of thioadatanserin and its dialkylated products as partial 5-HTR1A agonists and 5-HTR2A antagonists for potential use in depression and anxiety disorders

Author:

Evans Colleen A.ORCID,Zuluaga Andrea,Vasquez Matute Diego,Baradaran-Noviri Sarah,Perez-Cervantes Natalia,Siegler Maxime A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference8 articles.

1. Synthesis and SAR of adatanserin: novel adamantyl aryl-and heteroarylpiperazines with dual serotonin 5-HT1A and 5-HT2 activity as potential anxiolytic and antidepressants agents;Abou-Gharbia;J Med Chem.,1999

2. Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT1A/5-HT2 receptor ligand adatanserin;Dawson;Neurochem Intl J.,2002

3. Thioamides as useful synthons in the synthesis of heterocycles;Jagodzinski;Chem Rev.,2003

4. A survey of the role of noncovalent sulfur interactions in drug design;Beno;J Med Chem.,2015

5. https://adaa.org/about-adaa/press-room/facts-statistics Facts and Stats: Anxiety and Depression Association of America.

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