Solid-Phase PEGylation of Recombinant Interferon α-2a for Site-Specific Modification: Process Performance, Characterization, and in Vitro Bioactivity
Author:
Affiliation:
1. Bioprocessing Research Laboratory, Department of Chemical Engineering, Hanyang University, Ansan, Korea 426-791, and Department of Chemical Engineering, Yamaguchi University, Tokiwadai, Ube 755-8611, Japan
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology
Link
https://pubs.acs.org/doi/pdf/10.1021/bc060245m
Reference36 articles.
1. Biologic Responses to IFN-α Administration in Humans
2. Peginterferon-??-2a (40kD)
3. Rational Design of a Potent, Long-Lasting Form of Interferon: A 40 kDa Branched Polyethylene Glycol-Conjugated Interferon α-2a for the Treatment of Hepatitis C
4. Pegylation
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