A Practical Synthesis of m-Prostaglandin E Synthase-1 Inhibitor MK-7285
Author:
Affiliation:
1. Department of Process Research, Merck Frosst Centre for Therapeutic Research, 16711 Route Transcanadienne, Kirkland, Québec, Canada H9H 3L1
2. Department of Process Research, Merck Research Laboratories, Rahway, P.O. Box 2000, New Jersey 07065
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo901798d
Reference48 articles.
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2. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
3. Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2
4. Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway
5. Prostaglandin E synthase in the pathophysiology of arthritis
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