Development of a Practical Synthesis of a p38 Kinase Inhibitor via a Safe and Robust Amination-Reference-Cited by-同舟云学术

Development of a Practical Synthesis of a p38 Kinase Inhibitor via a Safe and Robust Amination

Published:2012-09-21 Issue:10 Volume:16 Page:1618-1625
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Shi Zhongping¹,Kiau Susanne¹,Lobben Paul¹,Hynes John²,Wu Hong²,Parlanti Luca¹,Discordia Robert¹,Doubleday Wendel W.¹,Leftheris Katerina²,Dyckman Alaric J.²,Wrobleski Stephen T.²,Dambalas Konstantinos¹,Tummala Srinivas¹,Leung Simon¹,Lo Ehrlic¹

Affiliation:

1. Chemical Development, Research & Development, Bristol-Myers Squibb Co., One Squibb Drive, P.O. Box 191, New Brunswick, New Jersey 08903-0191, United States

2. Medicinal Chemistry, Bristol-Myers Squibb Co., Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op300181r

Reference43 articles.

1. Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors

2. New dual inhibitors of EGFR and HER2 protein tyrosine kinases

3. Synthesis of amino acids and related compounds. 7. Convenient synthesis of 3-substituted pyrrole-2,4-dicarboxylic acid esters

4. 2-Benzoyl-2-ethoxycarbonylvinyl-1 and 2-benzoylamino-2-methoxy-carbonylvinyl-1 asN-protecting groups in peptide synthesis. Their application in the synthesis of dehydropeptide derivatives containingN-terminal 3-heteroarylamino-2,3-dehydroalanine

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