Optimization of Brain Penetrant 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet-Induced Obese Mice
Author:
Affiliation:
1. AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, United Kingdom
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm4016729
Reference42 articles.
1. 11β-Hydroxysteroid dehydrogenases: Key enzymes in determining tissue-specific glucocorticoid effects
2. 11β-Hydroxysteroid dehydrogenase: unexpected connections
3. Cortisol production in obesity
4. Inhibition of 11β-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?
5. Glucocorticoids and Cardiovascular Disease
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