Design, Synthesis, and Evaluation of Metabolism-Based Analogues of Haloperidol Incapable of Forming MPP+-like Species-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Metabolism-Based Analogues of Haloperidol Incapable of Forming MPP+-like Species

Published:2003-12-23 Issue:3 Volume:47 Page:497-508
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lyles-Eggleston M.¹,Altundas R.¹,Xia J.¹,Sikazwe D. M. N.¹,Fan P.¹,Yang Q.¹,Li S.¹,Zhang W.¹,Zhu X.¹,Schmidt A. W.¹,Vanase-Frawley M.¹,Shrihkande A.¹,Villalobos A.¹,Borne R. F.¹,Ablordeppey S. Y.¹

Affiliation:

1. Division of Basic Pharmaceutical Sciences, Florida A&M University, College of Pharmacy & Pharmaceutical Sciences, Tallahassee, Florida 32307, Department of Medicinal Chemistry, Laboratory of Applied Drug Design and Discovery, University of Mississippi, University, Mississippi 38677, and Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0301033

Reference30 articles.

1. Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

2. Antipsychotic drug doses and neuroleptic/dopamine receptors

3. Tardive dyskinesia after low-dose haloperidol

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