Practical and Efficient Strategy for Evaluating Oral Absolute Bioavailability with an Intravenous Microdose of a Stable Isotopically-Labeled Drug Using a Selected Reaction Monitoring Mass Spectrometry Assay
Author:
Affiliation:
1. Discovery Chemistry Synthesis, Bristol-Myers Squibb, Wallingford, Connecticut, United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ac3024558
Reference26 articles.
1. Microdosing: a valuable tool for accelerating drug development and the role of bioanalytical methods in meeting the challenge
2. Suspensions for intravenous (IV) injection: A review of development, preclinical and clinical aspects
3. The Application of Stable Isotopes to Studies of Drug Bioavailability and Bioequivalence
4. Pharmacokinetics and Absolute Bioavailability of Ribavirin in Healthy Volunteers as Determined by Stable-Isotope Methodology
5. Use of an Oral/Intravenous Dual-Label Stable-Isotope Protocol to Determine Folic Acid Bioavailability from Fortified Cereal Grain Foods in Women
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