Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases-Reference-Cited by-同舟云学术

Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases

Published:2011-10-03 Issue:20 Volume:54 Page:7299-7317
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Crosignani Stefano¹,Prêtre Adeline¹,Jorand-Lebrun Catherine¹,Fraboulet Gaële¹,Seenisamy Jeyaprakashnarayanan²,Augustine John Kallikat²,Missotten Marc¹,Humbert Yves¹,Cleva Christophe¹,Abla Nada¹,Daff Hamina¹,Schott Olivier¹,Schneider Manfred¹,Burgat-Charvillon Fabienne¹,Rivron Delphine¹,Hamernig Ingrid¹,Arrighi Jean-François¹,Gaudet Marilène¹,Zimmerli Simone C.¹,Juillard Pierre¹,Johnson Zoe¹

Affiliation:

1. Merck Serono S.A., 9 Chemin des Mines, CH-1202 Geneva, Switzerland

2. Syngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra IV Phase, Bommasandra, Jigani Link Road, Bangalore 560 099, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200866y

Reference48 articles.

1. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases

2. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2