Derivatives of (R)-1,11-Methyleneaporphine:  Synthesis, Structure, and Interactions with G-Protein Coupled Receptors

Author:

Linnanen Tero1,Brisander Magnus1,Unelius Lena1,Sundholm Göran1,Hacksell Uli1,Johansson Anette M.1

Affiliation:

1. Organic Pharmaceutical Chemistry, Uppsala University, Uppsala Biomedical Center, Box 574, SE-751 23 Uppsala, Sweden, Department of Structural Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden, Department of Lead Generation, Preclinical R&D, and Pharmaceutical and Analytical R&D, AstraZeneca R&D Södertälje, SE-151 85 Södertälje, Sweden, and ACADIA Pharmaceuticals, 3911 Sorrento Valley Boulevard, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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1. Aporphines: A privileged scaffold in CNS drug discovery;European Journal of Medicinal Chemistry;2023-08

2. Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT7AR ligands;Bioorganic & Medicinal Chemistry;2020-08

3. 8.01 Reduction of C=O to CHOH by Metal Hydrides;Comprehensive Organic Synthesis II;2014

4. 5-HT1A receptor pharmacophores to screen for off-target activity of α1-adrenoceptor antagonists;Journal of Computer-Aided Molecular Design;2013-04

5. Applications in Total Synthesis;Transition Metal Catalyzed Carbonylation Reactions;2013

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