A Mechanistic Hypothesis for the Cytochrome P450-Catalyzed Cis–Trans Isomerization of 4-Hydroxytamoxifen: An Unusual Redox Reaction-Reference-Cited by-同舟云学术

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A Mechanistic Hypothesis for the Cytochrome P450-Catalyzed Cis–Trans Isomerization of 4-Hydroxytamoxifen: An Unusual Redox Reaction

Published:2011-09-13 Issue:9 Volume:51 Page:2293-2301
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Gao Li¹,Tu Yaoquan¹,Wegman Pia²,Wingren Sten²,Eriksson Leif A.³

Affiliation:

1. Örebro Life Science Center, School of Science and Technology, Örebro University, 70182 Örebro, Sweden

2. Department of Health and Medical Sciences, Örebro University, 70182 Örebro, Sweden

3. School of Chemistry, National University of Ireland - Galway, Ireland

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ci2001082

Reference54 articles.

1. Tamoxifen: a most unlikely pioneering medicine

2. CYP2D6 Genotype, Antidepressant Use, and Tamoxifen Metabolism During Adjuvant Breast Cancer Treatment

3. Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6

4. A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism

5. Comparative binding affinities of tamoxifen, 4-hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: Correlation with blood levels in patients with metastatic breast cancer

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