Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists-Reference-Cited by-同舟云学术

Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists

Published:2011-09-09 Issue:19 Volume:54 Page:6969-6983
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ballatore Carlo¹²,Soper James H.²,Piscitelli Francesco¹,James Michael²,Huang Longchuan¹,Atasoylu Onur¹,Huryn Donna M.¹,Trojanowski John Q.²,Lee Virginia M.-Y.²,Brunden Kurt R.²,Smith Amos B.¹

Affiliation:

1. Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States

2. Center for Neurodegenerative Diseases Research, Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania, 3600 Spruce Street, Philadelphia, Pennsylvania 19104-6323, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200980u

Reference23 articles.

1. Bioisosterism: A Rational Approach in Drug Design

2. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

3. 5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods

4. Synthesis of Aureomycin Degradation Products. II

5. Structures of Cyclopentanepolyones

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