Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis-Reference-Cited by-同舟云学术

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Published:2014-11-20 Issue:23 Volume:57 Page:9855-9869
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brand Stephen¹,Norcross Neil R.¹,Thompson Stephen¹,Harrison Justin R.¹,Smith Victoria C.¹,Robinson David A.¹,Torrie Leah S.¹,McElroy Stuart P.¹,Hallyburton Irene¹,Norval Suzanne¹,Scullion Paul¹,Stojanovski Laste¹,Simeons Frederick R. C.¹,van Aalten Daan¹,Frearson Julie A.¹,Brenk Ruth¹,Fairlamb Alan H.¹,Ferguson Michael A. J.¹,Wyatt Paul G.¹,Gilbert Ian H.¹,Read Kevin D.¹

Affiliation:

1. Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, U.K.

Funder

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500809c

Reference34 articles.

1. Development of novel drugs for human African trypanosomiasis

2. Kinetoplastids: related protozoan pathogens, different diseases

3. State of the Art in African Trypanosome Drug Discovery