1. College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Korea, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Eoun-dong, Yuseong-gu, Daejeon 305-333, Korea, and AmorePacific Corporation, 314-1 Bora-ri, Yongin, Gyeonggi-do 449-729, Korea