Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6-Reference-Cited by-同舟云学术

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

Published:2008-07-22 Issue:15 Volume:51 Page:4370-4373
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kozikowski Alan P.¹,Tapadar Subhasish¹,Luchini Doris N.¹,Kim Ki Hwan¹,Billadeau Daniel D.¹

Affiliation:

1. Drug Discovery Program, Department of Medicinal Chemistry & Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, Division of Oncology Research, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8002894

Reference26 articles.

1. Non-Invasive Tests in Animal Models and Humans: A New Paradigm for Assessing Efficacy of Biologics Including Prebiotics and Probiotics

2. Anticancer activities of histone deacetylase inhibitors

3. Histone Deacetylase Inhibitors: From Bench to Clinic

4. Histone acetylation in chromatin structure and transcription

5. Review: Chromatin Structural Features and Targets That Regulate Transcription

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